Indian Journal of Public Health Research & Development

Nivedhaa Chezhian ¹, Lakshmi Thangavelu ², S. Rajeshkumar ², Deepa Gurunathan ³, R. V. Geetha ⁴, Anitha Roy ²

Affiliations
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
3 Professor, Department of Pedodontics & Preventive Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
4 Associate Professor, Department of Microbiology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN

Abstract

Aim: The aim is to study the interaction of Indole alkaloids against 2 oral carcinoma drug target by insilico docking using iGemdock tool.

Background: In this generation, technology has become so advanced that we are able to now achieve what was believed 20 years ago to be impossible. One such advancement is the in silico interactions. It is a virtual screening which enables us to bind two compounds and check the affinity of the binding. This helps us to first screen the activity of the two compounds before money, time and energy is spent in manually performing the activity and then arriving at a failure. We will be able to concentrate on the compounds which show us positive results in the in silico interactions, thus helping us in conserving time, expenditure and energy. Materials &

Method: The Oral carcinoma drug targets were identified by literature search and its 3D structure was downloaded from RCSB PDB (Protein Data Bank), which is a crystallographic database for the three-dimensional structural data of large biological molecules.

Results: From the above analysis it shows that ajmalicine shows good interaction with both the receptors also shows best fitness energy.

Keywords

Indole Alkaloids, Oral Carcinoma, Drug Target, Insilico Docking, Medication.

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C. Cinthura ¹, Lakshmi Thangavelu ², S. Rajeshkumar ², Deepa Gurunadhan ³, R. Pradeep Kumar ⁴, Anitha Roy ²

Affiliations
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
3 Professor, Department of Pedodontics & Preventive Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
4 Professor, Department of Public Health Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN

Abstract

Aim: To analyse the COX2 inhibitory activity of Abutilon indicum.

Objective: The main objective of this study is to analyse the COX2 inhibitory activity of Abutilon indicum.

Background: Prostaglandins are important mediators of the body’s response to pain and inflammation, and are formed from essential fatty acids found in cell membranes. This reaction is catalysed by cyclooxygenase, a membrane associated enzyme in two isoforms - COX-1 and COX-2. Abutilon indicum ,commonly known as the Indian mallow is well known for its therapeutic values and further study of its COX-2 inhibitory activity is beneficial.

Conclusion: Medicinal plants and shrubs which have little or no side effects have to be further investigated. Further study on its COX-2 inhibition will increase its therapeutic value also as an anti-inflammatory with added benefits

Keywords

Ethnomedicinal, Anti-Arthritic, COX2 Inhibition, Medicinal Uses, Prostaglandin.

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V. Deepak Nallaswamy ¹, Anitha Roy ², S. Rajeshkumar ², Lakshmi Thangavelu ², Devaraj Ezhilarasan ², M. Subha ³

Affiliations
1 Professor, Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN
3 Associate Professor, Department of Oral Medicine & Radiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN

Abstract

Introduction: Prosthetic complete dentures are commonly used by elderly people. These dentures on exposure to the oral environment forms biofilms. This harbours microorganisms and cause bacterial and fungal infections in the oral mucosa. Also cleansing the denture itself is a task for the elderly people. Any solution which clears the adhered component would help them better. Hence effervecense is a better choice to remove the biofilm.

Aim: To prepare effervescent denture cleansing granules with clove oil and to evaluate its antibacterial activity.

Materials and Method: The effervescent granules were prepared from citric acid, tartaric acid and sodium bicarbonate in a ratio of 1: 2: 3. Different concentrations of essential oil were mixed with sodium bicarbonate initially. The citric acid crystals were initially powered and then mixed with tartaric acid. Both these powders were mixed using geometric dilution, further sieved and packed in air tight glass container. The prepared clove effervescent denture cleansing granules were tested against Streptococcus mutants and Enterococcus faecalis after dissolving in sterile water. The fresh bacterial suspension was dispersed on the surface of nutrient agar plates. Different concentration of clove effervescent denture cleansing solution (50, 100 and 150 L) was incorporated into the wells and the plates were incubated at 37°C for 24 h. Zone of inhibition was recorded in each plate. Similarly the antifungal activity was evaluated using rose Bengal agar medium after inoculating with Candida albicans and incorporating the prepared effervescent denture cleansing solution.

Result: Clove mediated effervescent granules showed a dose dependent antibacterial activity against the tested microorganism with a maximum effect on Streptococcus mutans followed by Enterococcus faecalis. The different concentration showed similar inhibition in case of C. albicans.

Conclusion: The prepared clove mediated effervescent denture cleansing granules were found to be effective against S.mutans, E. faecalis and C. albicans . Hence it may be used for routine cleansing of denture to protect the denture users from infections such as denture stomatitis.

Keywords

Clove Oil, Effervescent Granules, Denture Cleanser, Denture Stomatitis.

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V. Deepak Nallaswamy ¹, Anitha Roy ², S. Rajeshkumar ², Lakshmi Thangavelu ², Devaraj Ezhilarasan ², M. Subha ³

Affiliations
1 Professor, Department of Prosthodontics, Saveetha Dental College,Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College,Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN
3 Reader, Department of Oral Medicine & Radiology, Saveetha Dental College,Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN

Abstract

Aim: To evaluate the antibacterial activity of dill oil mediated effervescent denture cleansing granules.

Materials and Method: The components such as citric acid, tartaric acid and sodium bicarbonate were taken in a ratio of 1: 2: 3 to prepare the effervescent granules by dry method. The citric acid crystals were powered first and then mixed with tartaric acid. Dill oil was mixed with sodium bicarbonate initially. Both the powders were mixed using geometric dilution, further sieved and packed in air tight containers. Different concentrations of the prepared dill effervescent denture cleansing solution was tested against Streptococcus mutants and Enterococcus faecalis and Candida albicans in their respective medium and the zone of inhibition was was recorded after incubation over night at 37° c.

Result: The effervescent granules prepared with dill oil showed good antibacterial activity against the tested microorganism such as Streptococcus mutans, Enterococcus faecalis and Candida albicans.

Conclusion: The effervescent denture cleansing granules prepared with dill oil were found to be effective against S. mutans, E. faecalis and Candida albicans. Hence it may be used for routine cleansing of denture to protect the denture users from infections such as denture stomatitis.

Keywords

Dill Oil, Effervescent Granules, Denture Cleanser, Denture Stomatitis.

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Deepak Nallaswamy Veeraiyan ¹, Lakshminarayanan Arivarasu ², Anitha Roy ², S. Rajeshkumar ², Lakshmi Thangavelu ², Devaraj Ezhilarasan ², M. Subha ³

Affiliations
1 Professor, Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN
3 Associate Professor, Department of Oral Medicine & Radiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN

Abstract

Aim: To prepare and evaluate the antibacterial activity of Coconut oil-mediated effervescent denture cleansing granules.

Materials and Method: The components such as citric acid, tartaric acid and sodium bicarbonate were taken in a ratio of 1: 2: 3 to prepare the effervescent granules by dry method. The citric acid crystals were powered first and then mixed with tartaric acid. Coconut oil was mixed with sodium bicarbonate initially. Both the powders were mixed using geometric dilution, further sieved and packed in air tight containers. Different concentrations of the prepared Coconut oil effervescent denture cleansing solution was tested against Streptococcus mutans and Enterococcus faecalis and Candida albicans in their respective medium and the zone of inhibition was recorded after incubation overnight at 37° c.

Result: The effervescent granules prepared using Coconut oil showed good dose dependent antimicrobial activity against the tested microorganism such as Streptococcus mutans, Enterococcus faecalis and Candida albicans.

Conclusion: The effervescent denture cleansing granules prepared with Coconut oil were found to be active against S. mutans, E. faecalis and Candida albicans at higher concentrations. Hence it may be used for routine cleansing of denture to protect the denture users from infections such as denture stomatitis.

Keywords

Coconut Oil, Effervescent Granules, Denture Cleanser, Denture Stomatitis.

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Deepak Nallaswamy Veeraiyan ¹, Lakshminarayan Arivarasu ², Anitha Roy ², S. Rajeshkumar ², Lakshmi Thangavelu ², Ezhilarasan Devaraj ², M. Subha ³

Affiliations
1 Professor, Departmentof Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN
3 Associate Professor, Department of Oral Medicine & Radiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, IN

Abstract

Aim: To evaluate the antimicrobial activity of oregano oil mediated effervescent denture cleansing granules.

Materials and Method: Effervescent granules were prepared using citric acid, tartaric acid and sodium bicarbonate in a ratio of 1: 2: 3 by dry method. The citric acid crystals were powdered first and then mixed with tartaric acid. Oregano Oil was mixed with sodium bicarbonate and incorporated with the acid by geometric dilution. It was then sieved and packed in airtight containers. Different concentrations of the prepared oregano effervescent denture cleansing solution was tested against Streptococcus mutans and Enterococcus faecalis and Candida albicans and the zone of inhibition was measured.

Result: The effervescent granules prepared with oregano oil showed good antimicrobial activity against the tested microorganisms such as Streptococcus mutans, Enterococcus faecalis and Candida albicans.

Conclusion: The effervescent denture cleansing granules prepared with oregano oil were found to be active against the test organisms especially against E faecalis.Hence it may be used for routine cleansing of denture to protect the denture users from infections such as denture stomatitis.

Keywords

Oregano Oil, Effervescent Granules, Denture Cleanser, Denture Stomatitis.

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